Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3644235..3644853 Replicon chromosome
Accession NZ_CP121155
Organism Escherichia coli strain E67

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P6H85_RS17645 Protein ID WP_001291435.1
Coordinates 3644635..3644853 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P6H85_RS17640 Protein ID WP_000344800.1
Coordinates 3644235..3644609 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H85_RS17630 (3639324) 3639324..3640517 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P6H85_RS17635 (3640540) 3640540..3643689 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P6H85_RS17640 (3644235) 3644235..3644609 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P6H85_RS17645 (3644635) 3644635..3644853 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P6H85_RS17650 (3645025) 3645025..3645576 + 552 WP_000102574.1 maltose O-acetyltransferase -
P6H85_RS17655 (3645692) 3645692..3646162 + 471 WP_000136192.1 YlaC family protein -
P6H85_RS17660 (3646326) 3646326..3647876 + 1551 WP_001361689.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P6H85_RS17665 (3647918) 3647918..3648271 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P6H85_RS17675 (3648650) 3648650..3648961 + 312 WP_000409911.1 MGMT family protein -
P6H85_RS17680 (3648992) 3648992..3649564 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275965 WP_001291435.1 NZ_CP121155:3644635-3644853 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275965 WP_000344800.1 NZ_CP121155:3644235-3644609 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References