Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2034278..2035062 Replicon chromosome
Accession NZ_CP121155
Organism Escherichia coli strain E67

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag P6H85_RS09715 Protein ID WP_000613626.1
Coordinates 2034278..2034772 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag P6H85_RS09720 Protein ID WP_001110447.1
Coordinates 2034769..2035062 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H85_RS09695 (2029471) 2029471..2030568 + 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -
P6H85_RS09700 (2030568) 2030568..2031509 + 942 WP_001305885.1 flagellar assembly peptidoglycan hydrolase FlgJ -
P6H85_RS09705 (2031575) 2031575..2033218 + 1644 WP_061092652.1 flagellar hook-associated protein FlgK -
P6H85_RS09710 (2033230) 2033230..2034183 + 954 WP_001212762.1 flagellar hook-associated protein FlgL -
P6H85_RS09715 (2034278) 2034278..2034772 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
P6H85_RS09720 (2034769) 2034769..2035062 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
P6H85_RS09725 (2035195) 2035195..2038380 - 3186 WP_061092653.1 ribonuclease E -
P6H85_RS09730 (2038953) 2038953..2039912 + 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T275957 WP_000613626.1 NZ_CP121155:c2034772-2034278 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT275957 WP_001110447.1 NZ_CP121155:c2035062-2034769 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References