Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1004906..1005560 Replicon chromosome
Accession NZ_CP121155
Organism Escherichia coli strain E67

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag P6H85_RS04875 Protein ID WP_000244765.1
Coordinates 1005153..1005560 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P6H85_RS04870 Protein ID WP_000354046.1
Coordinates 1004906..1005172 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H85_RS04850 (1000994) 1000994..1002427 - 1434 WP_063082439.1 6-phospho-beta-glucosidase BglA -
P6H85_RS04855 (1002472) 1002472..1002783 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
P6H85_RS04860 (1002947) 1002947..1003606 + 660 WP_000250274.1 hemolysin III family protein -
P6H85_RS04865 (1003683) 1003683..1004663 - 981 WP_049038218.1 tRNA-modifying protein YgfZ -
P6H85_RS04870 (1004906) 1004906..1005172 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P6H85_RS04875 (1005153) 1005153..1005560 + 408 WP_000244765.1 protein YgfX Toxin
P6H85_RS04880 (1005600) 1005600..1006121 - 522 WP_001055874.1 flavodoxin FldB -
P6H85_RS04885 (1006233) 1006233..1007129 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P6H85_RS04890 (1007154) 1007154..1007864 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P6H85_RS04895 (1007870) 1007870..1009603 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T275955 WP_000244765.1 NZ_CP121155:1005153-1005560 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275955 WP_000354046.1 NZ_CP121155:1004906-1005172 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References