Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4410888..4411385 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P6H84_RS21455 Protein ID WP_001173343.1
Coordinates 4410888..4411061 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag P6H84_RS21460 Protein ID WP_000398619.1
Coordinates 4411089..4411385 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS21445 (4407558) 4407558..4409015 + 1458 WP_061092757.1 dipeptide/tripeptide permease DtpC -
P6H84_RS21450 (4409252) 4409252..4410769 + 1518 WP_000003806.1 lysine--tRNA ligase -
P6H84_RS21455 (4410888) 4410888..4411061 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P6H84_RS21460 (4411089) 4411089..4411385 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P6H84_RS21465 (4411614) 4411614..4411886 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P6H84_RS21470 (4411898) 4411898..4412128 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
P6H84_RS21475 (4412309) 4412309..4413940 + 1632 WP_061092758.1 sensor histidine kinase -
P6H84_RS21480 (4413937) 4413937..4414656 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275944 WP_001173343.1 NZ_CP121153:c4411061-4410888 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT275944 WP_000398619.1 NZ_CP121153:c4411385-4411089 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References