Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4294169..4294691 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name relE Uniprot ID V0SDB6
Locus tag P6H84_RS20855 Protein ID WP_001105432.1
Coordinates 4294169..4294459 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag P6H84_RS20860 Protein ID WP_000212715.1
Coordinates 4294449..4294691 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS20840 (4289332) 4289332..4290987 + 1656 WP_001361372.1 alpha,alpha-phosphotrehalase -
P6H84_RS20845 (4291381) 4291381..4293519 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
P6H84_RS20850 (4293704) 4293704..4294168 + 465 WP_001009180.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P6H84_RS20855 (4294169) 4294169..4294459 - 291 WP_001105432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6H84_RS20860 (4294449) 4294449..4294691 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P6H84_RS20865 (4294883) 4294883..4295269 - 387 WP_001232253.1 cytochrome b562 -
P6H84_RS20870 (4295325) 4295325..4296677 - 1353 WP_001162172.1 metalloprotease PmbA -
P6H84_RS20875 (4296771) 4296771..4297322 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
P6H84_RS20880 (4297405) 4297405..4298778 - 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11311.21 Da        Isoelectric Point: 10.0238

>T275942 WP_001105432.1 NZ_CP121153:c4294459-4294169 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT275942 WP_000212715.1 NZ_CP121153:c4294691-4294449 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SDB6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References