275940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3696501..3697338 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name itaT Uniprot ID A0A1M0D5U3
Locus tag P6H84_RS17985 Protein ID WP_000227782.1
Coordinates 3696796..3697338 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID B1LJI1
Locus tag P6H84_RS17980 Protein ID WP_001353405.1
Coordinates 3696501..3696812 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS17955 (3691521) 3691521..3692468 + 948 WP_001239437.1 cytochrome o ubiquinol oxidase subunit II -
P6H84_RS17960 (3692490) 3692490..3694481 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
P6H84_RS17965 (3694471) 3694471..3695085 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
P6H84_RS17970 (3695085) 3695085..3695414 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
P6H84_RS17975 (3695426) 3695426..3696316 + 891 WP_000971327.1 heme o synthase -
P6H84_RS17980 (3696501) 3696501..3696812 + 312 WP_001353405.1 DUF1778 domain-containing protein Antitoxin
P6H84_RS17985 (3696796) 3696796..3697338 + 543 WP_000227782.1 GNAT family N-acetyltransferase Toxin
P6H84_RS17990 (3697394) 3697394..3698238 - 845 Protein_3524 tetratricopeptide repeat protein -
P6H84_RS17995 (3698645) 3698645..3700009 + 1365 WP_001000978.1 MFS transporter -
P6H84_RS18000 (3700137) 3700137..3700628 - 492 WP_001138904.1 nucleotide binding protein YajQ -
P6H84_RS18005 (3700796) 3700796..3701707 + 912 WP_000705841.1 2-dehydropantoate 2-reductase -
P6H84_RS18010 (3701670) 3701670..3702260 + 591 WP_001276320.1 protein deglycase YajL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19957.31 Da        Isoelectric Point: 9.1763

>T275940 WP_000227782.1 NZ_CP121153:3696796-3697338 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDIIYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCNFFEHVKIIHRALPIKGVYLDADPAAINFYTRLGFVQLSA
RPNVFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11370.09 Da        Isoelectric Point: 10.4825

>AT275940 WP_001353405.1 NZ_CP121153:3696501-3696812 [Escherichia coli]
MPGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0D5U3

Antitoxin

Source ID Structure
AlphaFold DB A0A829G7G3

References