Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3662411..3663029 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P6H84_RS17815 Protein ID WP_001291435.1
Coordinates 3662811..3663029 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P6H84_RS17810 Protein ID WP_000344800.1
Coordinates 3662411..3662785 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS17800 (3657500) 3657500..3658693 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P6H84_RS17805 (3658716) 3658716..3661865 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P6H84_RS17810 (3662411) 3662411..3662785 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P6H84_RS17815 (3662811) 3662811..3663029 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P6H84_RS17820 (3663201) 3663201..3663752 + 552 WP_000102574.1 maltose O-acetyltransferase -
P6H84_RS17825 (3663868) 3663868..3664338 + 471 WP_000136192.1 YlaC family protein -
P6H84_RS17830 (3664502) 3664502..3666052 + 1551 WP_001361689.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P6H84_RS17835 (3666094) 3666094..3666447 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P6H84_RS17845 (3666826) 3666826..3667137 + 312 WP_000409911.1 MGMT family protein -
P6H84_RS17850 (3667168) 3667168..3667740 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275939 WP_001291435.1 NZ_CP121153:3662811-3663029 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275939 WP_000344800.1 NZ_CP121153:3662411-3662785 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References