Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 981993..982647 Replicon chromosome
Accession NZ_CP121153
Organism Escherichia coli strain E57

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag P6H84_RS04775 Protein ID WP_000244765.1
Coordinates 982240..982647 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P6H84_RS04770 Protein ID WP_000354046.1
Coordinates 981993..982259 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H84_RS04750 (978081) 978081..979514 - 1434 WP_063082439.1 6-phospho-beta-glucosidase BglA -
P6H84_RS04755 (979559) 979559..979870 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
P6H84_RS04760 (980034) 980034..980693 + 660 WP_000250274.1 hemolysin III family protein -
P6H84_RS04765 (980770) 980770..981750 - 981 WP_049038218.1 tRNA-modifying protein YgfZ -
P6H84_RS04770 (981993) 981993..982259 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P6H84_RS04775 (982240) 982240..982647 + 408 WP_000244765.1 protein YgfX Toxin
P6H84_RS04780 (982687) 982687..983208 - 522 WP_001055874.1 flavodoxin FldB -
P6H84_RS04785 (983320) 983320..984216 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P6H84_RS04790 (984241) 984241..984951 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P6H84_RS04795 (984957) 984957..986690 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T275929 WP_000244765.1 NZ_CP121153:982240-982647 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275929 WP_000354046.1 NZ_CP121153:981993-982259 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References