Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 115563..116098 Replicon plasmid pE47-1
Accession NZ_CP121152
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag P6H31_RS26765 Protein ID WP_000222766.1
Coordinates 115811..116098 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag P6H31_RS26760 Protein ID WP_001132900.1
Coordinates 115563..115814 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS26720 (111168) 111168..111380 + 213 WP_012311405.1 hypothetical protein -
P6H31_RS26725 (111623) 111623..112084 + 462 WP_001233871.1 thermonuclease family protein -
P6H31_RS26730 (112130) 112130..112339 + 210 WP_001333231.1 hemolysin expression modulator Hha -
P6H31_RS26735 (112377) 112377..112950 + 574 Protein_150 DUF2726 domain-containing protein -
P6H31_RS26740 (113189) 113189..113449 + 261 WP_000083818.1 replication regulatory protein RepA -
P6H31_RS26745 (113475) 113475..113711 - 237 WP_223368648.1 replication protein RepA -
P6H31_RS26750 (113702) 113702..113749 + 48 WP_077822033.1 hypothetical protein -
P6H31_RS26755 (113742) 113742..114599 + 858 WP_000130940.1 incFII family plasmid replication initiator RepA -
P6H31_RS26760 (115563) 115563..115814 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P6H31_RS26765 (115811) 115811..116098 + 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / floR / aph(3')-Ia / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / qnrS2 vat 1..142233 142233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T275923 WP_000222766.1 NZ_CP121152:115811-116098 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT275923 WP_001132900.1 NZ_CP121152:115563-115814 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References