Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3981764..3982382 Replicon chromosome
Accession NZ_CP121151
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P6H31_RS19895 Protein ID WP_001291435.1
Coordinates 3982164..3982382 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P6H31_RS19890 Protein ID WP_000344800.1
Coordinates 3981764..3982138 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS19880 (3976853) 3976853..3978046 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P6H31_RS19885 (3978069) 3978069..3981218 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P6H31_RS19890 (3981764) 3981764..3982138 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P6H31_RS19895 (3982164) 3982164..3982382 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P6H31_RS19900 (3982554) 3982554..3983105 + 552 WP_000102568.1 maltose O-acetyltransferase -
P6H31_RS19905 (3983221) 3983221..3983691 + 471 WP_000136192.1 YlaC family protein -
P6H31_RS19910 (3983855) 3983855..3985405 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P6H31_RS19915 (3985447) 3985447..3985800 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P6H31_RS19925 (3986179) 3986179..3986490 + 312 WP_000409911.1 MGMT family protein -
P6H31_RS19930 (3986521) 3986521..3987093 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275913 WP_001291435.1 NZ_CP121151:3982164-3982382 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275913 WP_000344800.1 NZ_CP121151:3981764-3982138 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References