Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2829790..2830428 Replicon chromosome
Accession NZ_CP121151
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P6H31_RS14165 Protein ID WP_000813794.1
Coordinates 2830252..2830428 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P6H31_RS14160 Protein ID WP_001270286.1
Coordinates 2829790..2830206 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS14140 (2824942) 2824942..2825883 - 942 WP_001251319.1 ABC transporter permease -
P6H31_RS14145 (2825884) 2825884..2826897 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P6H31_RS14150 (2826915) 2826915..2828060 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
P6H31_RS14155 (2828305) 2828305..2829711 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
P6H31_RS14160 (2829790) 2829790..2830206 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P6H31_RS14165 (2830252) 2830252..2830428 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P6H31_RS14170 (2830650) 2830650..2830880 + 231 WP_000494244.1 YncJ family protein -
P6H31_RS14175 (2830972) 2830972..2832933 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P6H31_RS14180 (2833006) 2833006..2833542 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
P6H31_RS14185 (2833595) 2833595..2834809 + 1215 WP_001349372.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2834849..2836114 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T275910 WP_000813794.1 NZ_CP121151:c2830428-2830252 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT275910 WP_001270286.1 NZ_CP121151:c2830206-2829790 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References