Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1467071..1468694 Replicon chromosome
Accession NZ_CP121151
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag P6H31_RS07360 Protein ID WP_000088046.1
Coordinates 1467071..1468396 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag P6H31_RS07365 Protein ID WP_024136327.1
Coordinates 1468401..1468694 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS07330 (1463055) 1463055..1463906 - 852 WP_225517698.1 HNH endonuclease signature motif containing protein -
P6H31_RS07335 (1463928) 1463928..1464236 - 309 WP_001224687.1 hypothetical protein -
P6H31_RS07340 (1464785) 1464785..1465210 - 426 WP_001043843.1 hypothetical protein -
P6H31_RS07345 (1465464) 1465464..1466279 - 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
P6H31_RS07350 (1466292) 1466292..1466702 - 411 WP_000985911.1 hypothetical protein -
P6H31_RS07355 (1466804) 1466804..1467010 - 207 WP_062914745.1 hypothetical protein -
P6H31_RS07360 (1467071) 1467071..1468396 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
P6H31_RS07365 (1468401) 1468401..1468694 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
P6H31_RS07370 (1469298) 1469298..1469690 - 393 WP_000341066.1 hypothetical protein -
P6H31_RS07375 (1470063) 1470063..1470404 + 342 WP_001151575.1 hypothetical protein -
P6H31_RS07380 (1470496) 1470496..1470687 + 192 WP_000398480.1 hypothetical protein -
P6H31_RS07385 (1470737) 1470737..1471018 + 282 WP_000077926.1 hypothetical protein -
P6H31_RS07390 (1471359) 1471359..1471490 - 132 WP_000374059.1 hypothetical protein -
P6H31_RS07395 (1471581) 1471581..1472822 - 1242 WP_125282738.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T275903 WP_000088046.1 NZ_CP121151:c1468396-1467071 [Escherichia coli]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT275903 WP_024136327.1 NZ_CP121151:c1468694-1468401 [Escherichia coli]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References