Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1372298..1372923 Replicon chromosome
Accession NZ_CP121151
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P6H31_RS06855 Protein ID WP_000911330.1
Coordinates 1372525..1372923 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag P6H31_RS06850 Protein ID WP_000450524.1
Coordinates 1372298..1372525 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS06825 (1368101) 1368101..1368571 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
P6H31_RS06830 (1368571) 1368571..1369143 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
P6H31_RS06835 (1369289) 1369289..1370167 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
P6H31_RS06840 (1370184) 1370184..1371218 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
P6H31_RS06845 (1371431) 1371431..1372144 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
P6H31_RS06850 (1372298) 1372298..1372525 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
P6H31_RS06855 (1372525) 1372525..1372923 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
P6H31_RS06860 (1373070) 1373070..1373933 + 864 WP_001267508.1 neutral zinc metallopeptidase -
P6H31_RS06865 (1373948) 1373948..1375963 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
P6H31_RS06870 (1376037) 1376037..1376735 + 699 WP_000679823.1 esterase -
P6H31_RS06875 (1376845) 1376845..1377045 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T275902 WP_000911330.1 NZ_CP121151:1372525-1372923 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT275902 WP_000450524.1 NZ_CP121151:1372298-1372525 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References