Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 284708..285493 Replicon chromosome
Accession NZ_CP121151
Organism Escherichia coli strain E47

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag P6H31_RS01305 Protein ID WP_124062200.1
Coordinates 284981..285493 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag P6H31_RS01300 Protein ID WP_001277108.1
Coordinates 284708..284974 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H31_RS01280 (280366) 280366..281034 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
P6H31_RS01285 (281027) 281027..282085 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
P6H31_RS01290 (282330) 282330..283184 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
P6H31_RS01295 (283455) 283455..284558 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
P6H31_RS01300 (284708) 284708..284974 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
P6H31_RS01305 (284981) 284981..285493 + 513 WP_124062200.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
P6H31_RS01310 (285490) 285490..285873 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
P6H31_RS01315 (286297) 286297..287406 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
P6H31_RS01320 (287454) 287454..288380 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
P6H31_RS01325 (288377) 288377..289654 + 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
P6H31_RS01330 (289651) 289651..290418 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-145)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 19061.90 Da        Isoelectric Point: 6.9487

>T275898 WP_124062200.1 NZ_CP121151:284981-285493 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENALFFPTK
SIELLFTQSD

Download         Length: 513 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT275898 WP_001277108.1 NZ_CP121151:284708-284974 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References