275891

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3658305..3659142 Replicon chromosome
Accession NZ_CP121149
Organism Escherichia coli strain E14

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag P1I99_RS17860 Protein ID WP_000227784.1
Coordinates 3658600..3659142 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag P1I99_RS17855 Protein ID WP_001297137.1
Coordinates 3658305..3658616 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1I99_RS17830 (3653325) 3653325..3654272 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
P1I99_RS17835 (3654294) 3654294..3656285 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
P1I99_RS17840 (3656275) 3656275..3656889 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
P1I99_RS17845 (3656889) 3656889..3657218 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
P1I99_RS17850 (3657230) 3657230..3658120 + 891 WP_000971336.1 heme o synthase -
P1I99_RS17855 (3658305) 3658305..3658616 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
P1I99_RS17860 (3658600) 3658600..3659142 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
P1I99_RS17870 (3660085) 3660085..3660909 - 825 Protein_3496 tetratricopeptide repeat protein -
P1I99_RS17875 (3661317) 3661317..3662681 + 1365 WP_001000974.1 MFS transporter -
P1I99_RS17880 (3662915) 3662915..3663895 + 981 WP_000399648.1 IS110-like element IS621 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T275891 WP_000227784.1 NZ_CP121149:3658600-3659142 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT275891 WP_001297137.1 NZ_CP121149:3658305-3658616 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References