Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2612527..2613165 Replicon chromosome
Accession NZ_CP121149
Organism Escherichia coli strain E14

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P1I99_RS12750 Protein ID WP_000813794.1
Coordinates 2612989..2613165 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P1I99_RS12745 Protein ID WP_001270286.1
Coordinates 2612527..2612943 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1I99_RS12725 (2607679) 2607679..2608620 - 942 WP_001251315.1 ABC transporter permease -
P1I99_RS12730 (2608621) 2608621..2609634 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P1I99_RS12735 (2609652) 2609652..2610797 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
P1I99_RS12740 (2611042) 2611042..2612448 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
P1I99_RS12745 (2612527) 2612527..2612943 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P1I99_RS12750 (2612989) 2612989..2613165 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P1I99_RS12755 (2613387) 2613387..2613617 + 231 WP_000494244.1 YncJ family protein -
P1I99_RS12760 (2613709) 2613709..2615670 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P1I99_RS12765 (2615743) 2615743..2616279 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
P1I99_RS12770 (2616371) 2616371..2617546 + 1176 WP_001236215.1 BenE family transporter YdcO -
P1I99_RS12775 (2617586) 2617586..2617900 - 315 Protein_2501 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2612527..2629080 16553


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T275889 WP_000813794.1 NZ_CP121149:c2613165-2612989 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT275889 WP_001270286.1 NZ_CP121149:c2612943-2612527 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References