Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1407155..1407780 Replicon chromosome
Accession NZ_CP121149
Organism Escherichia coli strain E14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P1I99_RS06925 Protein ID WP_000911330.1
Coordinates 1407382..1407780 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag P1I99_RS06920 Protein ID WP_000450524.1
Coordinates 1407155..1407382 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1I99_RS06895 (1402958) 1402958..1403428 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
P1I99_RS06900 (1403428) 1403428..1404000 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
P1I99_RS06905 (1404146) 1404146..1405024 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
P1I99_RS06910 (1405041) 1405041..1406075 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
P1I99_RS06915 (1406288) 1406288..1407001 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
P1I99_RS06920 (1407155) 1407155..1407382 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1I99_RS06925 (1407382) 1407382..1407780 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
P1I99_RS06930 (1407927) 1407927..1408790 + 864 WP_001267498.1 neutral zinc metallopeptidase -
P1I99_RS06935 (1408805) 1408805..1410820 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
P1I99_RS06940 (1410894) 1410894..1411592 + 699 WP_000679812.1 esterase -
P1I99_RS06945 (1411673) 1411673..1411873 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T275882 WP_000911330.1 NZ_CP121149:1407382-1407780 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT275882 WP_000450524.1 NZ_CP121149:1407155-1407382 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References