Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4285994..4286589 Replicon chromosome
Accession NZ_CP121147
Organism Escherichia coli strain E20

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag P6H07_RS20740 Protein ID WP_000239581.1
Coordinates 4285994..4286344 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag P6H07_RS20745 Protein ID WP_001223213.1
Coordinates 4286338..4286589 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H07_RS20720 (4281448) 4281448..4282470 - 1023 WP_001361374.1 ABC transporter permease -
P6H07_RS20725 (4282484) 4282484..4283986 - 1503 WP_001095661.1 ATP-binding cassette domain-containing protein -
P6H07_RS20730 (4284119) 4284119..4285075 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
P6H07_RS20735 (4285385) 4285385..4285915 + 531 WP_000055072.1 inorganic diphosphatase -
P6H07_RS20740 (4285994) 4285994..4286344 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
P6H07_RS20745 (4286338) 4286338..4286589 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
P6H07_RS20750 (4286801) 4286801..4287142 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
P6H07_RS20755 (4287145) 4287145..4290924 - 3780 WP_000060873.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T275870 WP_000239581.1 NZ_CP121147:c4286344-4285994 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT275870 WP_001223213.1 NZ_CP121147:c4286589-4286338 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References