Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3217798..3218503 Replicon chromosome
Accession NZ_CP121147
Organism Escherichia coli strain E20

Toxin (Protein)


Gene name relE Uniprot ID A0A1M2J6W7
Locus tag P6H07_RS15490 Protein ID WP_000539524.1
Coordinates 3217798..3218184 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P6H07_RS15495 Protein ID WP_001280945.1
Coordinates 3218174..3218503 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H07_RS15470 (3213802) 3213802..3214428 + 627 WP_001295292.1 glutathione S-transferase GstB -
P6H07_RS15475 (3214425) 3214425..3215540 - 1116 WP_000555056.1 aldose sugar dehydrogenase YliI -
P6H07_RS15480 (3215651) 3215651..3216034 - 384 WP_000497137.1 biofilm formation regulator BssR -
P6H07_RS15485 (3216247) 3216247..3217572 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
P6H07_RS15490 (3217798) 3217798..3218184 + 387 WP_000539524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6H07_RS15495 (3218174) 3218174..3218503 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
P6H07_RS15500 (3218573) 3218573..3219890 - 1318 Protein_3043 diguanylate cyclase -
P6H07_RS15505 (3219898) 3219898..3222246 - 2349 WP_000950331.1 EAL domain-containing protein -
P6H07_RS15510 (3222423) 3222423..3223334 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14321.46 Da        Isoelectric Point: 9.9521

>T275864 WP_000539524.1 NZ_CP121147:3217798-3218184 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT275864 WP_001280945.1 NZ_CP121147:3218174-3218503 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2J6W7

Antitoxin

Source ID Structure

References