Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2034262..2035046 Replicon chromosome
Accession NZ_CP121147
Organism Escherichia coli strain E20

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag P6H07_RS09715 Protein ID WP_000613626.1
Coordinates 2034262..2034756 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag P6H07_RS09720 Protein ID WP_001110447.1
Coordinates 2034753..2035046 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H07_RS09695 (2029455) 2029455..2030552 + 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -
P6H07_RS09700 (2030552) 2030552..2031493 + 942 WP_001305885.1 flagellar assembly peptidoglycan hydrolase FlgJ -
P6H07_RS09705 (2031559) 2031559..2033202 + 1644 WP_061092652.1 flagellar hook-associated protein FlgK -
P6H07_RS09710 (2033214) 2033214..2034167 + 954 WP_001212762.1 flagellar hook-associated protein FlgL -
P6H07_RS09715 (2034262) 2034262..2034756 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
P6H07_RS09720 (2034753) 2034753..2035046 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
P6H07_RS09725 (2035179) 2035179..2038364 - 3186 WP_061092653.1 ribonuclease E -
P6H07_RS09730 (2038937) 2038937..2039896 + 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T275858 WP_000613626.1 NZ_CP121147:c2034756-2034262 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT275858 WP_001110447.1 NZ_CP121147:c2035046-2034753 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References