Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1004904..1005558 Replicon chromosome
Accession NZ_CP121147
Organism Escherichia coli strain E20

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag P6H07_RS04875 Protein ID WP_000244765.1
Coordinates 1005151..1005558 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P6H07_RS04870 Protein ID WP_000354046.1
Coordinates 1004904..1005170 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H07_RS04850 (1000992) 1000992..1002425 - 1434 WP_063082439.1 6-phospho-beta-glucosidase BglA -
P6H07_RS04855 (1002470) 1002470..1002781 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
P6H07_RS04860 (1002945) 1002945..1003604 + 660 WP_000250274.1 hemolysin III family protein -
P6H07_RS04865 (1003681) 1003681..1004661 - 981 WP_049038218.1 tRNA-modifying protein YgfZ -
P6H07_RS04870 (1004904) 1004904..1005170 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P6H07_RS04875 (1005151) 1005151..1005558 + 408 WP_000244765.1 protein YgfX Toxin
P6H07_RS04880 (1005598) 1005598..1006119 - 522 WP_001055874.1 flavodoxin FldB -
P6H07_RS04885 (1006231) 1006231..1007127 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P6H07_RS04890 (1007152) 1007152..1007862 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P6H07_RS04895 (1007868) 1007868..1009601 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T275856 WP_000244765.1 NZ_CP121147:1005151-1005558 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275856 WP_000354046.1 NZ_CP121147:1004904-1005170 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References