Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 185309..185921 Replicon chromosome
Accession NZ_CP121147
Organism Escherichia coli strain E20

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag P6H07_RS00840 Protein ID WP_000833473.1
Coordinates 185309..185494 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M2IVK0
Locus tag P6H07_RS00845 Protein ID WP_000499742.1
Coordinates 185511..185921 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H07_RS00825 (180775) 180775..182070 + 1296 WP_000985745.1 Fic family protein -
P6H07_RS00830 (182178) 182178..183716 + 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
P6H07_RS00835 (183757) 183757..184836 - 1080 WP_000061475.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
P6H07_RS00840 (185309) 185309..185494 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
P6H07_RS00845 (185511) 185511..185921 + 411 WP_000499742.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P6H07_RS00850 (186033) 186033..188012 - 1980 WP_001026863.1 glycoside hydrolase family 127 protein -
P6H07_RS00855 (188023) 188023..189423 - 1401 WP_000204814.1 MFS transporter -
P6H07_RS00860 (189649) 189649..190464 + 816 WP_000891820.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T275851 WP_000833473.1 NZ_CP121147:185309-185494 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15242.13 Da        Isoelectric Point: 4.4482

>AT275851 WP_000499742.1 NZ_CP121147:185511-185921 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2IVK0

References