Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 5120112..5120851 Replicon chromosome
Accession NZ_CP121145
Organism Klebsiella pneumoniae strain UHD-56_PH

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag P8T43_RS24810 Protein ID WP_032415800.1
Coordinates 5120112..5120597 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag P8T43_RS24815 Protein ID WP_003026799.1
Coordinates 5120585..5120851 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T43_RS24785 (P8T43_24780) 5115240..5116595 + 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -
P8T43_RS24790 (P8T43_24785) 5116841..5117131 + 291 WP_002921931.1 HTH-type transcriptional regulator -
P8T43_RS24795 (P8T43_24790) 5117384..5117596 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8T43_RS24800 (P8T43_24795) 5117695..5119314 - 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
P8T43_RS24805 (P8T43_24800) 5119616..5119768 - 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
P8T43_RS24810 (P8T43_24805) 5120112..5120597 - 486 WP_032415800.1 GNAT family N-acetyltransferase Toxin
P8T43_RS24815 (P8T43_24810) 5120585..5120851 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
P8T43_RS24820 (P8T43_24815) 5120984..5121412 - 429 WP_004901287.1 GFA family protein -
P8T43_RS24830 (P8T43_24825) 5123279..5125348 - 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5121613..5122338 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.46 Da        Isoelectric Point: 10.1428

>T275850 WP_032415800.1 NZ_CP121145:c5120597-5120112 [Klebsiella pneumoniae]
VGRITAPEPLCSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT275850 WP_003026799.1 NZ_CP121145:c5120851-5120585 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References