275847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4523194..4523851 Replicon chromosome
Accession NZ_CP121145
Organism Klebsiella pneumoniae strain UHD-56_PH

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P8T43_RS21830 Protein ID WP_002916310.1
Coordinates 4523194..4523604 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P8T43_RS21835 Protein ID WP_002916312.1
Coordinates 4523585..4523851 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T43_RS21810 (P8T43_21805) 4519194..4520927 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
P8T43_RS21815 (P8T43_21810) 4520933..4521646 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P8T43_RS21820 (P8T43_21815) 4521669..4522565 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P8T43_RS21825 (P8T43_21820) 4522666..4523187 + 522 WP_004144730.1 flavodoxin FldB -
P8T43_RS21830 (P8T43_21825) 4523194..4523604 - 411 WP_002916310.1 protein YgfX Toxin
P8T43_RS21835 (P8T43_21830) 4523585..4523851 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P8T43_RS21840 (P8T43_21835) 4524097..4525080 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
P8T43_RS21845 (P8T43_21840) 4525231..4525890 - 660 WP_002916317.1 hemolysin III family protein -
P8T43_RS21850 (P8T43_21845) 4526054..4526365 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
P8T43_RS21855 (P8T43_21850) 4526415..4527143 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P8T43_RS21860 (P8T43_21855) 4527262..4528695 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T275847 WP_002916310.1 NZ_CP121145:c4523604-4523194 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT275847 WP_002916312.1 NZ_CP121145:c4523851-4523585 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References