Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2629082..2630670 Replicon chromosome
Accession NZ_CP121145
Organism Klebsiella pneumoniae strain UHD-56_PH

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P8T43_RS12475 Protein ID WP_032414910.1
Coordinates 2629348..2630670 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P8T43_RS12470 Protein ID WP_002904790.1
Coordinates 2629082..2629348 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T43_RS12445 (P8T43_12440) 2624232..2625155 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
P8T43_RS12450 (P8T43_12445) 2625136..2626290 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
P8T43_RS12455 (P8T43_12450) 2626636..2628015 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
P8T43_RS12460 (P8T43_12455) 2627993..2628493 + 501 WP_032414907.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P8T43_RS12465 (P8T43_12460) 2628490..2628816 + 327 WP_032414908.1 hydroxyisourate hydrolase -
P8T43_RS12470 (P8T43_12465) 2629082..2629348 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P8T43_RS12475 (P8T43_12470) 2629348..2630670 + 1323 WP_032414910.1 type II toxin-antitoxin system HipA family toxin Toxin
P8T43_RS12480 (P8T43_12475) 2630687..2631979 - 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
P8T43_RS12485 (P8T43_12480) 2632121..2633125 - 1005 WP_004176196.1 fimbrial protein -
P8T43_RS12490 (P8T43_12485) 2633113..2635614 - 2502 WP_032414912.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49150.45 Da        Isoelectric Point: 7.5618

>T275842 WP_032414910.1 NZ_CP121145:2629348-2630670 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT275842 WP_002904790.1 NZ_CP121145:2629082-2629348 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References