Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4899806..4900463 Replicon chromosome
Accession NZ_CP121143
Organism Klebsiella pneumoniae strain UHD-57_PH

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P8T33_RS23715 Protein ID WP_002916310.1
Coordinates 4900053..4900463 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P8T33_RS23710 Protein ID WP_002916312.1
Coordinates 4899806..4900072 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T33_RS23685 (P8T33_23680) 4894962..4896395 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
P8T33_RS23690 (P8T33_23685) 4896514..4897242 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P8T33_RS23695 (P8T33_23690) 4897292..4897603 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
P8T33_RS23700 (P8T33_23695) 4897767..4898426 + 660 WP_002916317.1 hemolysin III family protein -
P8T33_RS23705 (P8T33_23700) 4898577..4899560 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
P8T33_RS23710 (P8T33_23705) 4899806..4900072 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P8T33_RS23715 (P8T33_23710) 4900053..4900463 + 411 WP_002916310.1 protein YgfX Toxin
P8T33_RS23720 (P8T33_23715) 4900470..4900991 - 522 WP_004144730.1 flavodoxin FldB -
P8T33_RS23725 (P8T33_23720) 4901092..4901988 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P8T33_RS23730 (P8T33_23725) 4902011..4902724 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P8T33_RS23735 (P8T33_23730) 4902730..4904463 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T275835 WP_002916310.1 NZ_CP121143:4900053-4900463 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT275835 WP_002916312.1 NZ_CP121143:4899806-4900072 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References