Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4302807..4303546 Replicon chromosome
Accession NZ_CP121143
Organism Klebsiella pneumoniae strain UHD-57_PH

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag P8T33_RS20735 Protein ID WP_032415800.1
Coordinates 4303061..4303546 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag P8T33_RS20730 Protein ID WP_003026799.1
Coordinates 4302807..4303073 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T33_RS20715 (P8T33_20710) 4298310..4300379 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
P8T33_RS20720 (P8T33_20715) 4300676..4302045 + 1370 WP_087830479.1 IS3 family transposase -
P8T33_RS20725 (P8T33_20720) 4302246..4302674 + 429 WP_004901287.1 GFA family protein -
P8T33_RS20730 (P8T33_20725) 4302807..4303073 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
P8T33_RS20735 (P8T33_20730) 4303061..4303546 + 486 WP_032415800.1 GNAT family N-acetyltransferase Toxin
P8T33_RS20740 (P8T33_20735) 4303890..4304042 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
P8T33_RS20745 (P8T33_20740) 4304344..4305963 + 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
P8T33_RS20750 (P8T33_20745) 4306062..4306274 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8T33_RS20755 (P8T33_20750) 4306527..4306817 - 291 WP_002921931.1 HTH-type transcriptional regulator -
P8T33_RS20760 (P8T33_20755) 4307063..4308418 - 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4301320..4302045 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.46 Da        Isoelectric Point: 10.1428

>T275832 WP_032415800.1 NZ_CP121143:4303061-4303546 [Klebsiella pneumoniae]
VGRITAPEPLCSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT275832 WP_003026799.1 NZ_CP121143:4302807-4303073 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References