Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 3700634..3702315 | Replicon | chromosome |
Accession | NZ_CP121143 | ||
Organism | Klebsiella pneumoniae strain UHD-57_PH |
Toxin (Protein)
Gene name | mosT | Uniprot ID | A0A2L0KL13 |
Locus tag | P8T33_RS17885 | Protein ID | WP_019704723.1 |
Coordinates | 3700634..3701551 (-) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | - |
Locus tag | P8T33_RS17890 | Protein ID | WP_032415850.1 |
Coordinates | 3701557..3702315 (-) | Length | 253 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P8T33_RS17865 (P8T33_17860) | 3695940..3697460 | + | 1521 | WP_032415851.1 | sugar ABC transporter ATP-binding protein | - |
P8T33_RS17870 (P8T33_17865) | 3697457..3698455 | + | 999 | WP_004186549.1 | ribose ABC transporter permease | - |
P8T33_RS17875 (P8T33_17870) | 3698486..3699427 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
P8T33_RS17880 (P8T33_17875) | 3699502..3700509 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
P8T33_RS17885 (P8T33_17880) | 3700634..3701551 | - | 918 | WP_019704723.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
P8T33_RS17890 (P8T33_17885) | 3701557..3702315 | - | 759 | WP_032415850.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
P8T33_RS17895 (P8T33_17890) | 3702401..3703129 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
P8T33_RS17900 (P8T33_17895) | 3703402..3705549 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
P8T33_RS17905 (P8T33_17900) | 3705779..3706465 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34632.07 Da Isoelectric Point: 5.4707
>T275830 WP_019704723.1 NZ_CP121143:c3701551-3700634 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28521.90 Da Isoelectric Point: 10.0870
>AT275830 WP_032415850.1 NZ_CP121143:c3702315-3701557 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|