Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3700634..3702315 Replicon chromosome
Accession NZ_CP121143
Organism Klebsiella pneumoniae strain UHD-57_PH

Toxin (Protein)


Gene name mosT Uniprot ID A0A2L0KL13
Locus tag P8T33_RS17885 Protein ID WP_019704723.1
Coordinates 3700634..3701551 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag P8T33_RS17890 Protein ID WP_032415850.1
Coordinates 3701557..3702315 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T33_RS17865 (P8T33_17860) 3695940..3697460 + 1521 WP_032415851.1 sugar ABC transporter ATP-binding protein -
P8T33_RS17870 (P8T33_17865) 3697457..3698455 + 999 WP_004186549.1 ribose ABC transporter permease -
P8T33_RS17875 (P8T33_17870) 3698486..3699427 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
P8T33_RS17880 (P8T33_17875) 3699502..3700509 + 1008 WP_004178300.1 carbohydrate kinase family protein -
P8T33_RS17885 (P8T33_17880) 3700634..3701551 - 918 WP_019704723.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
P8T33_RS17890 (P8T33_17885) 3701557..3702315 - 759 WP_032415850.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
P8T33_RS17895 (P8T33_17890) 3702401..3703129 - 729 WP_002885152.1 response regulator transcription factor -
P8T33_RS17900 (P8T33_17895) 3703402..3705549 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
P8T33_RS17905 (P8T33_17900) 3705779..3706465 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34632.07 Da        Isoelectric Point: 5.4707

>T275830 WP_019704723.1 NZ_CP121143:c3701551-3700634 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28521.90 Da        Isoelectric Point: 10.0870

>AT275830 WP_032415850.1 NZ_CP121143:c3702315-3701557 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2L0KL13


Antitoxin

Source ID Structure

References