Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1476328..1477916 Replicon chromosome
Accession NZ_CP121143
Organism Klebsiella pneumoniae strain UHD-57_PH

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P8T33_RS07295 Protein ID WP_032414910.1
Coordinates 1476328..1477650 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P8T33_RS07300 Protein ID WP_002904790.1
Coordinates 1477650..1477916 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T33_RS07280 (P8T33_07280) 1471384..1473885 + 2502 WP_032414912.1 fimbria/pilus outer membrane usher protein -
P8T33_RS07285 (P8T33_07285) 1473873..1474877 + 1005 WP_004176196.1 fimbrial protein -
P8T33_RS07290 (P8T33_07290) 1475019..1476311 + 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
P8T33_RS07295 (P8T33_07295) 1476328..1477650 - 1323 WP_032414910.1 type II toxin-antitoxin system HipA family toxin Toxin
P8T33_RS07300 (P8T33_07300) 1477650..1477916 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P8T33_RS07305 (P8T33_07305) 1478182..1478508 - 327 WP_032414908.1 hydroxyisourate hydrolase -
P8T33_RS07310 (P8T33_07310) 1478505..1479005 - 501 WP_032414907.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P8T33_RS07315 (P8T33_07315) 1478983..1480362 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
P8T33_RS07320 (P8T33_07320) 1480708..1481862 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
P8T33_RS07325 (P8T33_07325) 1481843..1482766 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49150.45 Da        Isoelectric Point: 7.5618

>T275826 WP_032414910.1 NZ_CP121143:c1477650-1476328 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT275826 WP_002904790.1 NZ_CP121143:c1477916-1477650 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References