Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3844048..3845636 Replicon chromosome
Accession NZ_CP121141
Organism Klebsiella pneumoniae strain UHD-58_PH

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P8T47_RS18490 Protein ID WP_032414910.1
Coordinates 3844314..3845636 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P8T47_RS18485 Protein ID WP_002904790.1
Coordinates 3844048..3844314 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T47_RS18460 (P8T47_18460) 3839198..3840121 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
P8T47_RS18465 (P8T47_18465) 3840102..3841256 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
P8T47_RS18470 (P8T47_18470) 3841602..3842981 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
P8T47_RS18475 (P8T47_18475) 3842959..3843459 + 501 WP_032414907.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P8T47_RS18480 (P8T47_18480) 3843456..3843782 + 327 WP_032414908.1 hydroxyisourate hydrolase -
P8T47_RS18485 (P8T47_18485) 3844048..3844314 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P8T47_RS18490 (P8T47_18490) 3844314..3845636 + 1323 WP_032414910.1 type II toxin-antitoxin system HipA family toxin Toxin
P8T47_RS18495 (P8T47_18495) 3845653..3846945 - 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
P8T47_RS18500 (P8T47_18500) 3847087..3848091 - 1005 WP_004176196.1 fimbrial protein -
P8T47_RS18505 (P8T47_18505) 3848079..3850580 - 2502 WP_032414912.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49150.45 Da        Isoelectric Point: 7.5618

>T275816 WP_032414910.1 NZ_CP121141:3844314-3845636 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT275816 WP_002904790.1 NZ_CP121141:3844048-3844314 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References