Detailed information of TA system TA275812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1619650..1621331
• Replicon: chromosome
• Accession: NZ_CP121141
• Organism: Klebsiella pneumoniae strain UHD-58_PH

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2L0KL13
• Locus tag: P8T47_RS07915
• Protein ID: WP_019704723.1
• Coordinates: 1620414..1621331 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: P8T47_RS07910
• Protein ID: WP_032415850.1
• Coordinates: 1619650..1620408 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8T47_RS07895 (P8T47_07895)	1615500..1616186	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
P8T47_RS07900 (P8T47_07900)	1616416..1618563	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
P8T47_RS07905 (P8T47_07905)	1618836..1619564	+	729	WP_002885152.1	response regulator transcription factor	-
P8T47_RS07910 (P8T47_07910)	1619650..1620408	+	759	WP_032415850.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
P8T47_RS07915 (P8T47_07915)	1620414..1621331	+	918	WP_019704723.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
P8T47_RS07920 (P8T47_07920)	1621456..1622463	-	1008	WP_004178300.1	carbohydrate kinase family protein	-
P8T47_RS07925 (P8T47_07925)	1622538..1623479	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
P8T47_RS07930 (P8T47_07930)	1623510..1624508	-	999	WP_004186549.1	ribose ABC transporter permease	-
P8T47_RS07935 (P8T47_07935)	1624505..1626025	-	1521	WP_032415851.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34632.07 Da
• Isoelectric Point: 5.4707

>T275812 WP_019704723.1 NZ_CP121141:1620414-1621331 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28521.90 Da
• Isoelectric Point: 10.0870

>AT275812 WP_032415850.1 NZ_CP121141:1619650-1620408 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A0A2L0KL13