Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 421501..422158 Replicon chromosome
Accession NZ_CP121141
Organism Klebsiella pneumoniae strain UHD-58_PH

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P8T47_RS02085 Protein ID WP_002916310.1
Coordinates 421501..421911 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P8T47_RS02090 Protein ID WP_002916312.1
Coordinates 421892..422158 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T47_RS02065 (P8T47_02065) 417501..419234 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
P8T47_RS02070 (P8T47_02070) 419240..419953 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P8T47_RS02075 (P8T47_02075) 419976..420872 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P8T47_RS02080 (P8T47_02080) 420973..421494 + 522 WP_004144730.1 flavodoxin FldB -
P8T47_RS02085 (P8T47_02085) 421501..421911 - 411 WP_002916310.1 protein YgfX Toxin
P8T47_RS02090 (P8T47_02090) 421892..422158 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P8T47_RS02095 (P8T47_02095) 422404..423387 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
P8T47_RS02100 (P8T47_02100) 423538..424197 - 660 WP_002916317.1 hemolysin III family protein -
P8T47_RS02105 (P8T47_02105) 424361..424672 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
P8T47_RS02110 (P8T47_02110) 424722..425450 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P8T47_RS02115 (P8T47_02115) 425569..427002 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T275807 WP_002916310.1 NZ_CP121141:c421911-421501 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT275807 WP_002916312.1 NZ_CP121141:c422158-421892 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References