Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4824999..4825738 Replicon chromosome
Accession NZ_CP121139
Organism Klebsiella pneumoniae strain UHD-4_PH

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag P8T35_RS23400 Protein ID WP_032415800.1
Coordinates 4824999..4825484 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag P8T35_RS23405 Protein ID WP_003026799.1
Coordinates 4825472..4825738 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T35_RS23375 (P8T35_23375) 4820127..4821482 + 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -
P8T35_RS23380 (P8T35_23380) 4821728..4822018 + 291 WP_002921931.1 HTH-type transcriptional regulator -
P8T35_RS23385 (P8T35_23385) 4822271..4822483 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8T35_RS23390 (P8T35_23390) 4822582..4824201 - 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
P8T35_RS23395 (P8T35_23395) 4824503..4824655 - 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
P8T35_RS23400 (P8T35_23400) 4824999..4825484 - 486 WP_032415800.1 GNAT family N-acetyltransferase Toxin
P8T35_RS23405 (P8T35_23405) 4825472..4825738 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
P8T35_RS23410 (P8T35_23410) 4825871..4826299 - 429 WP_004901287.1 GFA family protein -
P8T35_RS23420 (P8T35_23420) 4828166..4830235 - 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4826500..4827225 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.46 Da        Isoelectric Point: 10.1428

>T275804 WP_032415800.1 NZ_CP121139:c4825484-4824999 [Klebsiella pneumoniae]
VGRITAPEPLCSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT275804 WP_003026799.1 NZ_CP121139:c4825738-4825472 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References