Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4227360..4228017 Replicon chromosome
Accession NZ_CP121139
Organism Klebsiella pneumoniae strain UHD-4_PH

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P8T35_RS20420 Protein ID WP_002916310.1
Coordinates 4227360..4227770 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P8T35_RS20425 Protein ID WP_002916312.1
Coordinates 4227751..4228017 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T35_RS20400 (P8T35_20400) 4223360..4225093 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
P8T35_RS20405 (P8T35_20405) 4225099..4225812 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P8T35_RS20410 (P8T35_20410) 4225835..4226731 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P8T35_RS20415 (P8T35_20415) 4226832..4227353 + 522 WP_004144730.1 flavodoxin FldB -
P8T35_RS20420 (P8T35_20420) 4227360..4227770 - 411 WP_002916310.1 protein YgfX Toxin
P8T35_RS20425 (P8T35_20425) 4227751..4228017 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P8T35_RS20430 (P8T35_20430) 4228263..4229246 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
P8T35_RS20435 (P8T35_20435) 4229397..4230056 - 660 WP_002916317.1 hemolysin III family protein -
P8T35_RS20440 (P8T35_20440) 4230220..4230531 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
P8T35_RS20445 (P8T35_20445) 4230581..4231309 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P8T35_RS20450 (P8T35_20450) 4231428..4232861 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T275801 WP_002916310.1 NZ_CP121139:c4227770-4227360 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT275801 WP_002916312.1 NZ_CP121139:c4228017-4227751 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References