Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 993733..994352 Replicon chromosome
Accession NZ_CP121139
Organism Klebsiella pneumoniae strain UHD-4_PH

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag P8T35_RS04705 Protein ID WP_002892050.1
Coordinates 993733..993951 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag P8T35_RS04710 Protein ID WP_002892066.1
Coordinates 993978..994352 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T35_RS04670 (P8T35_04670) 989780..990043 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
P8T35_RS04675 (P8T35_04675) 990043..990183 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
P8T35_RS04680 (P8T35_04680) 990180..990878 - 699 WP_032414604.1 GNAT family protein -
P8T35_RS04685 (P8T35_04685) 990979..992430 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
P8T35_RS04690 (P8T35_04690) 992405..992875 - 471 WP_002892026.1 YlaC family protein -
P8T35_RS04695 (P8T35_04695) 992896..993036 + 141 WP_004147370.1 hypothetical protein -
P8T35_RS04700 (P8T35_04700) 993008..993574 - 567 WP_002892030.1 maltose O-acetyltransferase -
P8T35_RS04705 (P8T35_04705) 993733..993951 - 219 WP_002892050.1 HHA domain-containing protein Toxin
P8T35_RS04710 (P8T35_04710) 993978..994352 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
P8T35_RS04715 (P8T35_04715) 994838..997984 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
P8T35_RS04720 (P8T35_04720) 998007..999200 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275795 WP_002892050.1 NZ_CP121139:c993951-993733 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT275795 WP_002892066.1 NZ_CP121139:c994352-993978 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References