Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 381721..382531 Replicon chromosome
Accession NZ_CP121139
Organism Klebsiella pneumoniae strain UHD-4_PH

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag P8T35_RS01765 Protein ID WP_004178461.1
Coordinates 381998..382531 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag P8T35_RS01760 Protein ID WP_002887278.1
Coordinates 381721..381987 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T35_RS01740 (P8T35_01740) 377592..377936 - 345 WP_116288284.1 cation efflux system protein CusF -
P8T35_RS01745 (P8T35_01745) 377954..379339 - 1386 WP_026005908.1 efflux transporter outer membrane subunit -
P8T35_RS01750 (P8T35_01750) 379512..380195 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
P8T35_RS01755 (P8T35_01755) 380185..381618 + 1434 WP_032415907.1 Cu(+)/Ag(+) sensor histidine kinase -
P8T35_RS01760 (P8T35_01760) 381721..381987 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
P8T35_RS01765 (P8T35_01765) 381998..382531 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
P8T35_RS01770 (P8T35_01770) 382579..383700 - 1122 WP_012737335.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T275794 WP_004178461.1 NZ_CP121139:381998-382531 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT275794 WP_002887278.1 NZ_CP121139:381721-381987 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References