Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 267426..267942 Replicon chromosome
Accession NZ_CP121139
Organism Klebsiella pneumoniae strain UHD-4_PH

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag P8T35_RS01290 Protein ID WP_004178374.1
Coordinates 267658..267942 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag P8T35_RS01285 Protein ID WP_002886901.1
Coordinates 267426..267668 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T35_RS01270 (P8T35_01270) 263454..264194 + 741 WP_004186692.1 KDGP aldolase family protein -
P8T35_RS01275 (P8T35_01275) 264261..265415 + 1155 WP_032415878.1 lactonase family protein -
P8T35_RS01280 (P8T35_01280) 265438..267348 + 1911 WP_009486549.1 PRD domain-containing protein -
P8T35_RS01285 (P8T35_01285) 267426..267668 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8T35_RS01290 (P8T35_01290) 267658..267942 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T35_RS01295 (P8T35_01295) 267946..268410 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8T35_RS01300 (P8T35_01300) 268739..270877 - 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
P8T35_RS01305 (P8T35_01305) 271234..271977 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
P8T35_RS01310 (P8T35_01310) 271980..272153 - 174 WP_004222159.1 hypothetical protein -
P8T35_RS01315 (P8T35_01315) 272283..272546 + 264 WP_004152271.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T275793 WP_004178374.1 NZ_CP121139:267658-267942 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT275793 WP_002886901.1 NZ_CP121139:267426-267668 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References