Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4899797..4900454 Replicon chromosome
Accession NZ_CP121137
Organism Klebsiella pneumoniae strain UHD-33_PH

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P8T49_RS23720 Protein ID WP_002916310.1
Coordinates 4900044..4900454 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P8T49_RS23715 Protein ID WP_002916312.1
Coordinates 4899797..4900063 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T49_RS23690 (P8T49_23690) 4894953..4896386 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
P8T49_RS23695 (P8T49_23695) 4896505..4897233 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P8T49_RS23700 (P8T49_23700) 4897283..4897594 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
P8T49_RS23705 (P8T49_23705) 4897758..4898417 + 660 WP_002916317.1 hemolysin III family protein -
P8T49_RS23710 (P8T49_23710) 4898568..4899551 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
P8T49_RS23715 (P8T49_23715) 4899797..4900063 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P8T49_RS23720 (P8T49_23720) 4900044..4900454 + 411 WP_002916310.1 protein YgfX Toxin
P8T49_RS23725 (P8T49_23725) 4900461..4900982 - 522 WP_004144730.1 flavodoxin FldB -
P8T49_RS23730 (P8T49_23730) 4901083..4901979 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P8T49_RS23735 (P8T49_23735) 4902002..4902715 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P8T49_RS23740 (P8T49_23740) 4902721..4904454 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T275790 WP_002916310.1 NZ_CP121137:4900044-4900454 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT275790 WP_002916312.1 NZ_CP121137:4899797-4900063 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References