Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3543159..3543675 Replicon chromosome
Accession NZ_CP121137
Organism Klebsiella pneumoniae strain UHD-33_PH

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag P8T49_RS17090 Protein ID WP_004178374.1
Coordinates 3543159..3543443 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag P8T49_RS17095 Protein ID WP_002886901.1
Coordinates 3543433..3543675 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T49_RS17065 (P8T49_17065) 3538555..3538863 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
P8T49_RS17070 (P8T49_17070) 3538948..3539121 + 174 WP_004222159.1 hypothetical protein -
P8T49_RS17075 (P8T49_17075) 3539124..3539867 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
P8T49_RS17080 (P8T49_17080) 3540224..3542362 + 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
P8T49_RS17085 (P8T49_17085) 3542691..3543155 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8T49_RS17090 (P8T49_17090) 3543159..3543443 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T49_RS17095 (P8T49_17095) 3543433..3543675 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8T49_RS17100 (P8T49_17100) 3543753..3545663 - 1911 WP_009486549.1 PRD domain-containing protein -
P8T49_RS17105 (P8T49_17105) 3545686..3546840 - 1155 WP_032415878.1 lactonase family protein -
P8T49_RS17110 (P8T49_17110) 3546907..3547647 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T275784 WP_004178374.1 NZ_CP121137:c3543443-3543159 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT275784 WP_002886901.1 NZ_CP121137:c3543675-3543433 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References