Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3428570..3429380 Replicon chromosome
Accession NZ_CP121137
Organism Klebsiella pneumoniae strain UHD-33_PH

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag P8T49_RS16610 Protein ID WP_004178461.1
Coordinates 3428570..3429103 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag P8T49_RS16615 Protein ID WP_002887278.1
Coordinates 3429114..3429380 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T49_RS16605 (P8T49_16605) 3427401..3428522 + 1122 WP_012737335.1 cupin domain-containing protein -
P8T49_RS16610 (P8T49_16610) 3428570..3429103 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
P8T49_RS16615 (P8T49_16615) 3429114..3429380 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
P8T49_RS16620 (P8T49_16620) 3429483..3430916 - 1434 WP_032415907.1 Cu(+)/Ag(+) sensor histidine kinase -
P8T49_RS16625 (P8T49_16625) 3430906..3431589 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
P8T49_RS16630 (P8T49_16630) 3431762..3433147 + 1386 WP_026005908.1 efflux transporter outer membrane subunit -
P8T49_RS16635 (P8T49_16635) 3433165..3433509 + 345 WP_116288284.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T275783 WP_004178461.1 NZ_CP121137:c3429103-3428570 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT275783 WP_002887278.1 NZ_CP121137:c3429380-3429114 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References