Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1778304..1778820 Replicon chromosome
Accession NZ_CP121135
Organism Klebsiella pneumoniae strain UHD-41_PH

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag P8T41_RS08715 Protein ID WP_004178374.1
Coordinates 1778536..1778820 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag P8T41_RS08710 Protein ID WP_002886901.1
Coordinates 1778304..1778546 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T41_RS08695 (P8T41_08695) 1774332..1775072 + 741 WP_004186692.1 KDGP aldolase family protein -
P8T41_RS08700 (P8T41_08700) 1775139..1776293 + 1155 WP_032415878.1 lactonase family protein -
P8T41_RS08705 (P8T41_08705) 1776316..1778226 + 1911 WP_009486549.1 PRD domain-containing protein -
P8T41_RS08710 (P8T41_08710) 1778304..1778546 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8T41_RS08715 (P8T41_08715) 1778536..1778820 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T41_RS08720 (P8T41_08720) 1778824..1779288 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8T41_RS08725 (P8T41_08725) 1779617..1781755 - 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
P8T41_RS08730 (P8T41_08730) 1782112..1782855 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
P8T41_RS08735 (P8T41_08735) 1782858..1783031 - 174 WP_004222159.1 hypothetical protein -
P8T41_RS08740 (P8T41_08740) 1783116..1783424 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T275768 WP_004178374.1 NZ_CP121135:1778536-1778820 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT275768 WP_002886901.1 NZ_CP121135:1778304-1778546 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References