Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 5069075..5069814 Replicon chromosome
Accession NZ_CP121133
Organism Klebsiella pneumoniae strain UHD-45_PH

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag P8T31_RS24570 Protein ID WP_032415800.1
Coordinates 5069075..5069560 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag P8T31_RS24575 Protein ID WP_003026799.1
Coordinates 5069548..5069814 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T31_RS24545 (P8T31_24545) 5064203..5065558 + 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -
P8T31_RS24550 (P8T31_24550) 5065804..5066094 + 291 WP_002921931.1 HTH-type transcriptional regulator -
P8T31_RS24555 (P8T31_24555) 5066347..5066559 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8T31_RS24560 (P8T31_24560) 5066658..5068277 - 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
P8T31_RS24565 (P8T31_24565) 5068579..5068731 - 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
P8T31_RS24570 (P8T31_24570) 5069075..5069560 - 486 WP_032415800.1 GNAT family N-acetyltransferase Toxin
P8T31_RS24575 (P8T31_24575) 5069548..5069814 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
P8T31_RS24580 (P8T31_24580) 5069947..5070375 - 429 WP_004901287.1 GFA family protein -
P8T31_RS24590 (P8T31_24590) 5072242..5074311 - 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5070576..5071301 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.46 Da        Isoelectric Point: 10.1428

>T275760 WP_032415800.1 NZ_CP121133:c5069560-5069075 [Klebsiella pneumoniae]
VGRITAPEPLCSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT275760 WP_003026799.1 NZ_CP121133:c5069814-5069548 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References