Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2574770..2576358 Replicon chromosome
Accession NZ_CP121133
Organism Klebsiella pneumoniae strain UHD-45_PH

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P8T31_RS12215 Protein ID WP_032414910.1
Coordinates 2575036..2576358 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag P8T31_RS12210 Protein ID WP_002904790.1
Coordinates 2574770..2575036 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T31_RS12185 (P8T31_12185) 2569920..2570843 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
P8T31_RS12190 (P8T31_12190) 2570824..2571978 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
P8T31_RS12195 (P8T31_12195) 2572324..2573703 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
P8T31_RS12200 (P8T31_12200) 2573681..2574181 + 501 WP_032414907.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
P8T31_RS12205 (P8T31_12205) 2574178..2574504 + 327 WP_032414908.1 hydroxyisourate hydrolase -
P8T31_RS12210 (P8T31_12210) 2574770..2575036 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P8T31_RS12215 (P8T31_12215) 2575036..2576358 + 1323 WP_032414910.1 type II toxin-antitoxin system HipA family toxin Toxin
P8T31_RS12220 (P8T31_12220) 2576375..2577667 - 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
P8T31_RS12225 (P8T31_12225) 2577809..2578813 - 1005 WP_004176196.1 fimbrial protein -
P8T31_RS12230 (P8T31_12230) 2578801..2581302 - 2502 WP_032414912.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49150.45 Da        Isoelectric Point: 7.5618

>T275752 WP_032414910.1 NZ_CP121133:2575036-2576358 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT275752 WP_002904790.1 NZ_CP121133:2574770-2575036 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References