Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 509296..509812 Replicon chromosome
Accession NZ_CP121133
Organism Klebsiella pneumoniae strain UHD-45_PH

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag P8T31_RS02440 Protein ID WP_004178374.1
Coordinates 509528..509812 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag P8T31_RS02435 Protein ID WP_002886901.1
Coordinates 509296..509538 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T31_RS02420 (P8T31_02420) 505324..506064 + 741 WP_004186692.1 KDGP aldolase family protein -
P8T31_RS02425 (P8T31_02425) 506131..507285 + 1155 WP_032415878.1 lactonase family protein -
P8T31_RS02430 (P8T31_02430) 507308..509218 + 1911 WP_009486549.1 PRD domain-containing protein -
P8T31_RS02435 (P8T31_02435) 509296..509538 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8T31_RS02440 (P8T31_02440) 509528..509812 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T31_RS02445 (P8T31_02445) 509816..510280 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8T31_RS02450 (P8T31_02450) 510609..512747 - 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
P8T31_RS02455 (P8T31_02455) 513104..513847 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
P8T31_RS02460 (P8T31_02460) 513850..514023 - 174 WP_004222159.1 hypothetical protein -
P8T31_RS02465 (P8T31_02465) 514108..514416 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T275749 WP_004178374.1 NZ_CP121133:509528-509812 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT275749 WP_002886901.1 NZ_CP121133:509296-509538 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References