Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 350665..352346 | Replicon | chromosome |
| Accession | NZ_CP121133 | ||
| Organism | Klebsiella pneumoniae strain UHD-45_PH | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A2L0KL13 |
| Locus tag | P8T31_RS01640 | Protein ID | WP_019704723.1 |
| Coordinates | 351429..352346 (+) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | P8T31_RS01635 | Protein ID | WP_032415850.1 |
| Coordinates | 350665..351423 (+) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P8T31_RS01620 (P8T31_01620) | 346515..347201 | - | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
| P8T31_RS01625 (P8T31_01625) | 347431..349578 | - | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| P8T31_RS01630 (P8T31_01630) | 349851..350579 | + | 729 | WP_002885152.1 | response regulator transcription factor | - |
| P8T31_RS01635 (P8T31_01635) | 350665..351423 | + | 759 | WP_032415850.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| P8T31_RS01640 (P8T31_01640) | 351429..352346 | + | 918 | WP_019704723.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| P8T31_RS01645 (P8T31_01645) | 352471..353478 | - | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| P8T31_RS01650 (P8T31_01650) | 353553..354494 | - | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| P8T31_RS01655 (P8T31_01655) | 354525..355523 | - | 999 | WP_004186549.1 | ribose ABC transporter permease | - |
| P8T31_RS01660 (P8T31_01660) | 355520..357040 | - | 1521 | WP_032415851.1 | sugar ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34632.07 Da Isoelectric Point: 5.4707
>T275748 WP_019704723.1 NZ_CP121133:351429-352346 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28521.90 Da Isoelectric Point: 10.0870
>AT275748 WP_032415850.1 NZ_CP121133:350665-351423 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|