Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3743955..3744694 Replicon chromosome
Accession NZ_CP121131
Organism Klebsiella pneumoniae strain UHD-50_PH

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag P8T45_RS18135 Protein ID WP_032415800.1
Coordinates 3744209..3744694 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag P8T45_RS18130 Protein ID WP_003026799.1
Coordinates 3743955..3744221 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T45_RS18115 (P8T45_18120) 3739458..3741527 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
P8T45_RS18120 (P8T45_18125) 3741824..3743193 + 1370 WP_087830479.1 IS3 family transposase -
P8T45_RS18125 (P8T45_18130) 3743394..3743822 + 429 WP_004901287.1 GFA family protein -
P8T45_RS18130 (P8T45_18135) 3743955..3744221 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
P8T45_RS18135 (P8T45_18140) 3744209..3744694 + 486 WP_032415800.1 GNAT family N-acetyltransferase Toxin
P8T45_RS18140 (P8T45_18145) 3745038..3745190 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
P8T45_RS18145 (P8T45_18150) 3745492..3747111 + 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
P8T45_RS18150 (P8T45_18155) 3747210..3747422 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8T45_RS18155 (P8T45_18160) 3747675..3747965 - 291 WP_002921931.1 HTH-type transcriptional regulator -
P8T45_RS18160 (P8T45_18165) 3748211..3749566 - 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3742468..3743193 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.46 Da        Isoelectric Point: 10.1428

>T275742 WP_032415800.1 NZ_CP121131:3744209-3744694 [Klebsiella pneumoniae]
VGRITAPEPLCSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT275742 WP_003026799.1 NZ_CP121131:3743955-3744221 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References