Detailed information of TA system TA275740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3141783..3143464
• Replicon: chromosome
• Accession: NZ_CP121131
• Organism: Klebsiella pneumoniae strain UHD-50_PH

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2L0KL13
• Locus tag: P8T45_RS15285
• Protein ID: WP_019704723.1
• Coordinates: 3141783..3142700 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: P8T45_RS15290
• Protein ID: WP_032415850.1
• Coordinates: 3142706..3143464 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8T45_RS15265 (P8T45_15270)	3137089..3138609	+	1521	WP_032415851.1	sugar ABC transporter ATP-binding protein	-
P8T45_RS15270 (P8T45_15275)	3138606..3139604	+	999	WP_004186549.1	ribose ABC transporter permease	-
P8T45_RS15275 (P8T45_15280)	3139635..3140576	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
P8T45_RS15280 (P8T45_15285)	3140651..3141658	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
P8T45_RS15285 (P8T45_15290)	3141783..3142700	-	918	WP_019704723.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
P8T45_RS15290 (P8T45_15295)	3142706..3143464	-	759	WP_032415850.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
P8T45_RS15295 (P8T45_15300)	3143550..3144278	-	729	WP_002885152.1	response regulator transcription factor	-
P8T45_RS15300 (P8T45_15305)	3144551..3146698	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
P8T45_RS15305 (P8T45_15310)	3146928..3147614	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34632.07 Da
• Isoelectric Point: 5.4707

>T275740 WP_019704723.1 NZ_CP121131:c3142700-3141783 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28521.90 Da
• Isoelectric Point: 10.0870

>AT275740 WP_032415850.1 NZ_CP121131:c3143464-3142706 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A0A2L0KL13