Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2984317..2984833 Replicon chromosome
Accession NZ_CP121131
Organism Klebsiella pneumoniae strain UHD-50_PH

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag P8T45_RS14485 Protein ID WP_004178374.1
Coordinates 2984317..2984601 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag P8T45_RS14490 Protein ID WP_002886901.1
Coordinates 2984591..2984833 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T45_RS14460 (P8T45_14465) 2979713..2979976 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
P8T45_RS14465 (P8T45_14470) 2980106..2980279 + 174 WP_004222159.1 hypothetical protein -
P8T45_RS14470 (P8T45_14475) 2980282..2981025 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
P8T45_RS14475 (P8T45_14480) 2981382..2983520 + 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
P8T45_RS14480 (P8T45_14485) 2983849..2984313 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8T45_RS14485 (P8T45_14490) 2984317..2984601 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8T45_RS14490 (P8T45_14495) 2984591..2984833 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8T45_RS14495 (P8T45_14500) 2984911..2986821 - 1911 WP_009486549.1 PRD domain-containing protein -
P8T45_RS14500 (P8T45_14505) 2986844..2987998 - 1155 WP_032415878.1 lactonase family protein -
P8T45_RS14505 (P8T45_14510) 2988065..2988805 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T275739 WP_004178374.1 NZ_CP121131:c2984601-2984317 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT275739 WP_002886901.1 NZ_CP121131:c2984833-2984591 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References