Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4364507..4365164 Replicon chromosome
Accession NZ_CP121129
Organism Klebsiella pneumoniae strain UHD-49_PH

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag P8T37_RS21090 Protein ID WP_002916310.1
Coordinates 4364507..4364917 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P8T37_RS21095 Protein ID WP_002916312.1
Coordinates 4364898..4365164 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T37_RS21070 (P8T37_21070) 4360507..4362240 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
P8T37_RS21075 (P8T37_21075) 4362246..4362959 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P8T37_RS21080 (P8T37_21080) 4362982..4363878 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P8T37_RS21085 (P8T37_21085) 4363979..4364500 + 522 WP_004144730.1 flavodoxin FldB -
P8T37_RS21090 (P8T37_21090) 4364507..4364917 - 411 WP_002916310.1 protein YgfX Toxin
P8T37_RS21095 (P8T37_21095) 4364898..4365164 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P8T37_RS21100 (P8T37_21100) 4365410..4366393 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
P8T37_RS21105 (P8T37_21105) 4366544..4367203 - 660 WP_002916317.1 hemolysin III family protein -
P8T37_RS21110 (P8T37_21110) 4367367..4367678 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
P8T37_RS21115 (P8T37_21115) 4367728..4368456 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
P8T37_RS21120 (P8T37_21120) 4368575..4370008 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T275726 WP_002916310.1 NZ_CP121129:c4364917-4364507 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT275726 WP_002916312.1 NZ_CP121129:c4365164-4364898 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References