Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 245999..247680 Replicon chromosome
Accession NZ_CP121129
Organism Klebsiella pneumoniae strain UHD-49_PH

Toxin (Protein)


Gene name mosT Uniprot ID A0A2L0KL13
Locus tag P8T37_RS01155 Protein ID WP_019704723.1
Coordinates 246763..247680 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag P8T37_RS01150 Protein ID WP_032415850.1
Coordinates 245999..246757 (+) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T37_RS01135 (P8T37_01135) 241849..242535 - 687 WP_004151733.1 tetratricopeptide repeat protein -
P8T37_RS01140 (P8T37_01140) 242765..244912 - 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
P8T37_RS01145 (P8T37_01145) 245185..245913 + 729 WP_002885152.1 response regulator transcription factor -
P8T37_RS01150 (P8T37_01150) 245999..246757 + 759 WP_032415850.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
P8T37_RS01155 (P8T37_01155) 246763..247680 + 918 WP_019704723.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
P8T37_RS01160 (P8T37_01160) 247805..248812 - 1008 WP_004178300.1 carbohydrate kinase family protein -
P8T37_RS01165 (P8T37_01165) 248887..249828 - 942 WP_002885156.1 ABC transporter substrate-binding protein -
P8T37_RS01170 (P8T37_01170) 249859..250857 - 999 WP_004186549.1 ribose ABC transporter permease -
P8T37_RS01175 (P8T37_01175) 250854..252374 - 1521 WP_032415851.1 sugar ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34632.07 Da        Isoelectric Point: 5.4707

>T275717 WP_019704723.1 NZ_CP121129:246763-247680 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28521.90 Da        Isoelectric Point: 10.0870

>AT275717 WP_032415850.1 NZ_CP121129:245999-246757 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQSQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2L0KL13


Antitoxin

Source ID Structure

References